Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

Brett Waybrant, Timothy R. Pearce, Ping Wang, Srinand Sreevatsan, Efrosini Kokkoli

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

Original languageEnglish (US)
Pages (from-to)10043-10045
Number of pages3
JournalChemical Communications
Volume48
Issue number80
DOIs
StatePublished - Sep 12 2012

Fingerprint Dive into the research topics of 'Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX'. Together they form a unique fingerprint.

  • Cite this