Development and characterization of a tissue-engineered cardiovascular valve

Jeremiah Wille; Michael Neidert; Robert T Tranquillo

Development and characterization of a tissue-engineered cardiovascular valve

Jeremiah Wille
, Michael Neidert
, Robert T Tranquillo

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Development and characterization of a tissue-engineered cardiovascular valve, was analyzed. A biopolymer reconstituted into a hydrated network of native fibrils, such as type I collagen or more recently fibrin due to its ability to stimulate increased cell-secreted extracellular matrix (ECM). Appropriate cells are entrapped in this biopolymer network as it forms following injection of a cell suspension containing monomers into a mold. This mold impart proper geometry to the valve and also provide a constraint to cell-mediated network compaction resulting in aligned fibrils similar to that of native valves.

Original language	English (US)
Title of host publication	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Number of pages	1
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country/Territory	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

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@inproceedings{0c68489d0d974b2c862f60db6a5afc8d,

title = "Development and characterization of a tissue-engineered cardiovascular valve",

abstract = "Development and characterization of a tissue-engineered cardiovascular valve, was analyzed. A biopolymer reconstituted into a hydrated network of native fibrils, such as type I collagen or more recently fibrin due to its ability to stimulate increased cell-secreted extracellular matrix (ECM). Appropriate cells are entrapped in this biopolymer network as it forms following injection of a cell suspension containing monomers into a mold. This mold impart proper geometry to the valve and also provide a constraint to cell-mediated network compaction resulting in aligned fibrils similar to that of native valves.",

author = "Jeremiah Wille and Michael Neidert and Tranquillo, \{Robert T\}",

year = "2002",

month = dec,

day = "1",

language = "English (US)",

booktitle = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products",

note = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products ; Conference date: 13-10-2002 Through 16-10-2002",

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TY - GEN

T1 - Development and characterization of a tissue-engineered cardiovascular valve

AU - Wille, Jeremiah

AU - Neidert, Michael

AU - Tranquillo, Robert T

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Development and characterization of a tissue-engineered cardiovascular valve, was analyzed. A biopolymer reconstituted into a hydrated network of native fibrils, such as type I collagen or more recently fibrin due to its ability to stimulate increased cell-secreted extracellular matrix (ECM). Appropriate cells are entrapped in this biopolymer network as it forms following injection of a cell suspension containing monomers into a mold. This mold impart proper geometry to the valve and also provide a constraint to cell-mediated network compaction resulting in aligned fibrils similar to that of native valves.

AB - Development and characterization of a tissue-engineered cardiovascular valve, was analyzed. A biopolymer reconstituted into a hydrated network of native fibrils, such as type I collagen or more recently fibrin due to its ability to stimulate increased cell-secreted extracellular matrix (ECM). Appropriate cells are entrapped in this biopolymer network as it forms following injection of a cell suspension containing monomers into a mold. This mold impart proper geometry to the valve and also provide a constraint to cell-mediated network compaction resulting in aligned fibrils similar to that of native valves.

UR - https://www.scopus.com/pages/publications/18644381350

UR - https://www.scopus.com/pages/publications/18644381350#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:18644381350

BT - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

T2 - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Y2 - 13 October 2002 through 16 October 2002

ER -

Development and characterization of a tissue-engineered cardiovascular valve

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