Development and characterization of a tissue-engineered cardiovascular valve

Jeremiah Wille, Michael Neidert, Robert T Tranquillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Development and characterization of a tissue-engineered cardiovascular valve, was analyzed. A biopolymer reconstituted into a hydrated network of native fibrils, such as type I collagen or more recently fibrin due to its ability to stimulate increased cell-secreted extracellular matrix (ECM). Appropriate cells are entrapped in this biopolymer network as it forms following injection of a cell suspension containing monomers into a mold. This mold impart proper geometry to the valve and also provide a constraint to cell-mediated network compaction resulting in aligned fibrils similar to that of native valves.

Original languageEnglish (US)
Title of host publicationThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Number of pages1
StatePublished - Dec 1 2002
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: Oct 13 2002Oct 16 2002

Other

OtherThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period10/13/0210/16/02

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