Development and applications of a model for cellular response to multiple chemotactic cues

K. J. Painter, P. K. Maini, Hans G Othmer

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The chemotactic response of a cell population to a single chemical species has been characterized experimentally for many cell types and has been extensively studied from a theoretical standpoint. However, cells frequently have multiple receptor types and can detect and respond chemotactically to more than one chemical. How these signals are integrated within the cell is not known, and we therefore adopt a macroscopic phenomenological approach to this problem. In this paper we derive and analyze chemotactic models based on partial differential (chemotaxis) equations for cell movement in response to multiple chemotactic cues. Our derivation generalizes the approach of Othmer and Stevens [29], who have recently developed a modeling framework for studying different chemotactic responses to a single chemical species. The importance of such a generalization is illustrated by the effect of multiple chemical cues on the chemotactic sensitivity and the spatial pattern of cell densities in several examples. We demonstrate that the model can generate the complex patterns observed on the skin of certain animal species and we indicate how the chemotactic response can be viewed as a form of positional indicator.

Original languageEnglish (US)
Pages (from-to)285-314
Number of pages30
JournalJournal of Mathematical Biology
Issue number4
StatePublished - Oct 2000


  • Cell movement
  • Chemotaxis
  • Multiple signals
  • Pattern formation


Dive into the research topics of 'Development and applications of a model for cellular response to multiple chemotactic cues'. Together they form a unique fingerprint.

Cite this