Abstract
The average analytical recovery of succinylacetone added to urine and separated by capillary gas chromatography was 69% for solvent extraction and 72% for anion exchange separation. Treating succinylacetone with hydroxylamine hydrochloride at a pH of less than 5 caused formation of a derivative separated by capillary gas chromatography into two isomers: 3-methyl-5-isoxazole propionate and 5-methyl-3-isoxazole propionate as their trimethylsilyl derivatives (molecular weight 227). In a pH greater than or equal to 5, succinylacetone dioxime was formed and separated into 3 isomers as their trimethylsilyl derivatives (molecular weight 404).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-215 |
| Number of pages | 5 |
| Journal | Journal of Chromatographic Science |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1984 |