Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography

Jie Hong Guo; Xing Hong Li; Xue Li Cao; Yan Li; Xi Zhi Wang; Xiao Bai Xu

doi:10.1016/j.chroma.2009.02.021

Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography

Jie Hong Guo, Xing Hong Li, Xue Li Cao, Yan Li, Xi Zhi Wang, Xiao Bai Xu

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, dispersive liquid-liquid microextraction (DLLME) combined with ultra-high-pressure liquid chromatography (UHPLC)-tunable ultraviolet detection (TUV), has been developed for pre-concentration and determination of triclosan (TCS), triclocarban (TCC) and methyl-triclosan (M-TCS) in aqueous samples. The key factors, including the kind and volume of extraction solvent and dispersive solvent, extraction time, salt effect and pH, which probably affect the extraction efficiencies were examined and optimized. Under the optimum conditions, linearity of the method was observed in the range of 0.0500-100 μg L^-1 for TCS, 0.0250-50.0 μg L^-1 for TCC, and 0.500-100 μg L^-1 for M-TCS, respectively, with correlation coefficients (r²) > 0.9945. The limits of detection (LODs) ranged from 45.1 to 236 ng L^-1. TCS in domestic waters was detected with the concentration of 2.08 μg L^-1. The spiked recoveries of three target compounds in river water, irrigating water, reclaimed water and domestic water samples were achieved in the range of 96.4-121%, 64.3-84.9%, 77.2-115% and 75.5-106%, respectively. As a result, this method can be successfully applied for the rapid and convenient determination of TCS, TCC and M-TCS in real water samples.

Original language	English (US)
Pages (from-to)	3038-3043
Number of pages	6
Journal	Journal of Chromatography A
Volume	1216
Issue number	15
DOIs	https://doi.org/10.1016/j.chroma.2009.02.021
State	Published - Apr 10 2009
Externally published	Yes

Bibliographical note

Funding Information:
We acknowledge financial support of this work by the National High Technology Research and Development Program (“863” Program) of China (122007AA061601) and the National Natural Science Foundation of China and the National Basic Research Program of China (20607026, 20877092).

Keywords

Aqueous sample
DLLME
Pharmaceuticals and personal care products
UHPLC

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10.1016/j.chroma.2009.02.021

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Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography. / Guo, Jie Hong; Li, Xing Hong; Cao, Xue Li; Li, Yan; Wang, Xi Zhi; Xu, Xiao Bai.

In: Journal of Chromatography A, Vol. 1216, No. 15, 10.04.2009, p. 3038-3043.

Research output: Contribution to journal › Article › peer-review

@article{8c34e890d5b74986a6bf06d67efa82a8,

title = "Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography",

abstract = "In this study, dispersive liquid-liquid microextraction (DLLME) combined with ultra-high-pressure liquid chromatography (UHPLC)-tunable ultraviolet detection (TUV), has been developed for pre-concentration and determination of triclosan (TCS), triclocarban (TCC) and methyl-triclosan (M-TCS) in aqueous samples. The key factors, including the kind and volume of extraction solvent and dispersive solvent, extraction time, salt effect and pH, which probably affect the extraction efficiencies were examined and optimized. Under the optimum conditions, linearity of the method was observed in the range of 0.0500-100 μg L-1 for TCS, 0.0250-50.0 μg L-1 for TCC, and 0.500-100 μg L-1 for M-TCS, respectively, with correlation coefficients (r2) > 0.9945. The limits of detection (LODs) ranged from 45.1 to 236 ng L-1. TCS in domestic waters was detected with the concentration of 2.08 μg L-1. The spiked recoveries of three target compounds in river water, irrigating water, reclaimed water and domestic water samples were achieved in the range of 96.4-121%, 64.3-84.9%, 77.2-115% and 75.5-106%, respectively. As a result, this method can be successfully applied for the rapid and convenient determination of TCS, TCC and M-TCS in real water samples.",

keywords = "Aqueous sample, DLLME, Pharmaceuticals and personal care products, UHPLC",

author = "Guo, {Jie Hong} and Li, {Xing Hong} and Cao, {Xue Li} and Yan Li and Wang, {Xi Zhi} and Xu, {Xiao Bai}",

note = "Funding Information: We acknowledge financial support of this work by the National High Technology Research and Development Program (“863” Program) of China (122007AA061601) and the National Natural Science Foundation of China and the National Basic Research Program of China (20607026, 20877092).",

year = "2009",

month = apr,

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doi = "10.1016/j.chroma.2009.02.021",

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T1 - Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography

AU - Guo, Jie Hong

AU - Li, Xing Hong

AU - Cao, Xue Li

AU - Li, Yan

AU - Wang, Xi Zhi

AU - Xu, Xiao Bai

N1 - Funding Information: We acknowledge financial support of this work by the National High Technology Research and Development Program (“863” Program) of China (122007AA061601) and the National Natural Science Foundation of China and the National Basic Research Program of China (20607026, 20877092).

PY - 2009/4/10

Y1 - 2009/4/10

N2 - In this study, dispersive liquid-liquid microextraction (DLLME) combined with ultra-high-pressure liquid chromatography (UHPLC)-tunable ultraviolet detection (TUV), has been developed for pre-concentration and determination of triclosan (TCS), triclocarban (TCC) and methyl-triclosan (M-TCS) in aqueous samples. The key factors, including the kind and volume of extraction solvent and dispersive solvent, extraction time, salt effect and pH, which probably affect the extraction efficiencies were examined and optimized. Under the optimum conditions, linearity of the method was observed in the range of 0.0500-100 μg L-1 for TCS, 0.0250-50.0 μg L-1 for TCC, and 0.500-100 μg L-1 for M-TCS, respectively, with correlation coefficients (r2) > 0.9945. The limits of detection (LODs) ranged from 45.1 to 236 ng L-1. TCS in domestic waters was detected with the concentration of 2.08 μg L-1. The spiked recoveries of three target compounds in river water, irrigating water, reclaimed water and domestic water samples were achieved in the range of 96.4-121%, 64.3-84.9%, 77.2-115% and 75.5-106%, respectively. As a result, this method can be successfully applied for the rapid and convenient determination of TCS, TCC and M-TCS in real water samples.

AB - In this study, dispersive liquid-liquid microextraction (DLLME) combined with ultra-high-pressure liquid chromatography (UHPLC)-tunable ultraviolet detection (TUV), has been developed for pre-concentration and determination of triclosan (TCS), triclocarban (TCC) and methyl-triclosan (M-TCS) in aqueous samples. The key factors, including the kind and volume of extraction solvent and dispersive solvent, extraction time, salt effect and pH, which probably affect the extraction efficiencies were examined and optimized. Under the optimum conditions, linearity of the method was observed in the range of 0.0500-100 μg L-1 for TCS, 0.0250-50.0 μg L-1 for TCC, and 0.500-100 μg L-1 for M-TCS, respectively, with correlation coefficients (r2) > 0.9945. The limits of detection (LODs) ranged from 45.1 to 236 ng L-1. TCS in domestic waters was detected with the concentration of 2.08 μg L-1. The spiked recoveries of three target compounds in river water, irrigating water, reclaimed water and domestic water samples were achieved in the range of 96.4-121%, 64.3-84.9%, 77.2-115% and 75.5-106%, respectively. As a result, this method can be successfully applied for the rapid and convenient determination of TCS, TCC and M-TCS in real water samples.

KW - Aqueous sample

KW - DLLME

KW - Pharmaceuticals and personal care products

KW - UHPLC

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DO - 10.1016/j.chroma.2009.02.021

M3 - Article

C2 - 19249787

AN - SCOPUS:62249205010

VL - 1216

SP - 3038

EP - 3043

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 15

ER -

Determination of triclosan, triclocarban and methyl-triclosan in aqueous samples by dispersive liquid-liquid microextraction combined with rapid liquid chromatography

Abstract

Bibliographical note

Keywords

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