Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using ¹⁷O-enriched substrates and substrate analogues

Keyphrases

• Phosphonates 100%
• Epoxides 100%
• Active Sites 100%
• Substrate Analog 100%
• Chelates 100%
• Fe(II) 100%
• Hydroxyl 100%
• Epoxidase 100%
• Substrate-binding Mode 100%
• Keto 66%
• Phosphonate Groups 66%
• Diols 33%
• Antibiotics 33%
• Non-heme 33%
• Regio 33%
• Chemical Synthesis 33%
• Functional Groups 33%
• EPR Spectra 33%
• Hydroxyl Group 33%
• Hydrogen Abstraction 33%
• Core Structure 33%
• X-ray Crystal Structure 33%
• Monodentate 33%
• Carbon Chain 33%
• Fe Ions 33%
• Analogue Compound 33%
• Oxidase 33%
• Multiple Orientations 33%
• Direct Binding 33%
• Hydroxyl Substituent 33%
• Terminal Group 33%
• EPR Analysis 33%
• Fosfomycin 33%
• Acid Yield 33%
• Fixed Orientation 33%
• Activated Oxygen Species 33%

Biochemistry, Genetics and Molecular Biology

• Active Site 100%
• Substrate Analog 100%
• X Ray 50%
• Solution and Solubility 50%
• Crystal Structure 50%
• Oxidase 50%
• Oxidoreductase 50%