Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action

Emily S. Pfeiffer, Hiroshi Hiasa

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We used an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.

Original languageEnglish (US)
Pages (from-to)3410-3412
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number9
DOIs
StatePublished - Sep 2007

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