TY - JOUR
T1 - Determination of ten iodinated X-ray contrast media by solid-phase extraction and ultra-high performance liquid chromatography coupled with high-resolution orbitrap mass spectrometry
AU - Cheng, Xinying
AU - Ji, Qiuyi
AU - Wang, Xuebing
AU - Guo, Jiehong
AU - Chen, Xianxian
AU - He, Huan
AU - Yu, Nanyang
AU - Li, Shiyin
AU - Yang, Shaogui
AU - Zhang, Limin
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/6
Y1 - 2022/6
N2 - A highly sensitive method for the simultaneous determination of ten iodinated X-ray contrast media (ICM) in environmental water samples was developed, in which samples were pretreated using solid-phase extraction and analyzed by ultra-high performance liquid chromatography coupled with high-resolution orbitrap mass spectrometry. A combination of two ENVI-Chrom P cartridges was selected due to its high recoveries of ICM. The optimized sample pH, flow rate, eluent type, and volume of eluent were 2.0, 6 mL/min, MeOH/ACN (50:50, v/v), and 6 mL, respectively. The developed method was used for the tap, surface, and waste water sample analysis, and exhibited satisfactory accuracy (80.8-118.5%), high precision (0.1-11.6%), and low detection limits (0.3-1.0 ng/L). These results indicate that this method is highly effective for the simultaneous determination of trace-level ICM in the aquatic environment.
AB - A highly sensitive method for the simultaneous determination of ten iodinated X-ray contrast media (ICM) in environmental water samples was developed, in which samples were pretreated using solid-phase extraction and analyzed by ultra-high performance liquid chromatography coupled with high-resolution orbitrap mass spectrometry. A combination of two ENVI-Chrom P cartridges was selected due to its high recoveries of ICM. The optimized sample pH, flow rate, eluent type, and volume of eluent were 2.0, 6 mL/min, MeOH/ACN (50:50, v/v), and 6 mL, respectively. The developed method was used for the tap, surface, and waste water sample analysis, and exhibited satisfactory accuracy (80.8-118.5%), high precision (0.1-11.6%), and low detection limits (0.3-1.0 ng/L). These results indicate that this method is highly effective for the simultaneous determination of trace-level ICM in the aquatic environment.
KW - Environmental water samples
KW - Iodinated X-ray contrast media
KW - Solid-phase extraction
KW - UPLC-HRMS
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U2 - 10.1016/j.microc.2022.107270
DO - 10.1016/j.microc.2022.107270
M3 - Article
AN - SCOPUS:85124301097
SN - 0026-265X
VL - 177
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 107270
ER -