Determination of quality of life-related utilities for health states relevant to ovarian cancer diagnosis and treatment

Laura J. Havrilesky, Gloria Broadwater, Debra M. Davis, Kimberly C. Nolte, J. Cory Barnett, Evan R. Myers, Shalini Kulasingam

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82 Scopus citations


Objectives: (1) To define a set of health state descriptions related to screening, diagnosis, prognosis, and toxicities relevant to ovarian cancer; (2) To derive a set of quality of life-related utilities to be used for cost-effectiveness analyses. Methods: A comprehensive list of health states was developed to represent the experiences of diagnostic testing for ovarian cancer, natural history of ovarian cancer (e.g., newly diagnosed early stage ovarian cancer, recurrent progressive ovarian cancer) and the most common chemotherapy-related toxicities (e.g. alopecia, peripheral neuropathy, pain, neutropenia, fatigue). Valuation of each health state was obtained through individual interviews of 13 ovarian cancer patients and 37 female members of the general public. Interviews employed visual analog score (VAS) and time trade off (TTO) methods of health state valuation. Results: Mean TTO-derived utilities were higher than VAS-derived utilities by 0.118 U (p < 0.0001). Mean VAS-derived utilities for screening tests were 0.83 and 0.81 for true negative blood test and ultrasound; 0.79 and 0.78 for false negative blood test and ultrasound, respectively. Patients and volunteers generally agreed in their preference ranking of chemotherapy-associated states, with lowest rankings being given to febrile neutropenia, grades 3-4 fatigue, and grades 3-4 nausea/vomiting. For 55% of chemotherapy-associated health states, the average utility assigned was higher for patients than for volunteers. Conclusions: This study establishes societal preferences for a number of health states related to screening, diagnosis and treatment of ovarian cancer that can be used for assessing the cost-effectiveness of different ovarian cancer screening and treatment regimens.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalGynecologic oncology
Issue number2
StatePublished - May 2009

Bibliographical note

Funding Information:
LH is supported by a grant from the American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation.

Funding Information:
This study was funded by the NCI through Duke Comprehensive Cancer Center Core Support Grant #5P30-CA14236.


  • Health state
  • Ovarian cancer
  • Quality of life
  • Utility


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