Determination of Neutrophil Half-Life

Amos S. Deinard, Arthur R. Page, David D. Dale, Anthony S. Fauci, Sheldon M. Wolff

Research output: Contribution to journalLetterpeer-review


To the Editor: The leukocyte kinetic studies of patients on alternate-day steroid therapy by Dale, Fauci and Wolff (N Engl J Med 291:1154–1158, 1974) must be questioned because the method that they chose for measuring neutrophil half-life is only valid for a steady-state situation. The authors started their studies three to four hours after a dose of prednisone. With such timing, a steady state definitely does not exist, as is evident from our observations that the absolute peripheral neutrophil count rises.

Original languageEnglish (US)
Pages (from-to)533-534
Number of pages2
JournalNew England Journal of Medicine
Issue number10
StatePublished - Mar 6 1975


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