Determination of maternal rabies virus neutralizing antibody in young puppies

Uzma Farid Durrani, Sagar Mal Goyal, Asim Khalid Mahmood, Cathleen Hanlon, Susan Moore, Muhammad Waqas, Raheela Akhtar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A pre-vaccination serological study was conducted on 100 puppies (< 3 months age), in rabies endemic Lahore city of Pakistan, to evaluate their maternal rabies virus neutralizing antibody titer (mRVNA). All puppies were whelped by dams regularly vaccinated with high quality inactivated rabies vaccines. Rapid Fluorescence Focus Inhibition Technique (RFFIT) revealed mRVNA titer (>0.5 IU/mL) in 29 puppies while 48 puppies showed mRVNA titer less than minimum protective level (0.2-0.4 IU/mL). RFFIT did not reveal mRVNA in 23 puppies that were declared lacking maternal rabies immunity. One basis of findings of this study it was concluded that puppies population lacking maternal rabies immunity is one of the responsible factors for increasing incidence of rabies in humans and dogs living in Lahore, Pakistan.

Original languageEnglish (US)
Pages (from-to)1147-1149
Number of pages3
JournalPakistan Journal of Zoology
Issue number3
StatePublished - 2017

Bibliographical note

Publisher Copyright:
Copyright 2017 Zoological Society of Pakistan.


  • Maternal rabies virus neutralizing antibody (mRVNA)
  • Puppies
  • Rapid fluorescent focus inhibition technique (REFFIT)


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