TY - JOUR
T1 - Determination of loading and unloading of cryoprotective agents in tissues and tissue-equivalents
AU - Devireddy, Ramachandra
AU - Sankha, Bhowmick
AU - Neidert, Michael
AU - Tranquillo, Robert T
AU - Bischof, John C
PY - 2000
Y1 - 2000
N2 - In this study, numerical predictions of CPA loading and unloading in tissues were carried out based on, i) microscale membrane transport formulations and ii) macroscale diffusion of CPA using classical mass diffusion principles (Fick's Law) with a sink term for the CPA movement into the cells. The results will be used to develop a rational design for loading and unloading of CPAs in tissues and tissue engineered equivalents and to reduce the time of contact between potentially toxic CPAs and tissues prior to and after the freezing process.
AB - In this study, numerical predictions of CPA loading and unloading in tissues were carried out based on, i) microscale membrane transport formulations and ii) macroscale diffusion of CPA using classical mass diffusion principles (Fick's Law) with a sink term for the CPA movement into the cells. The results will be used to develop a rational design for loading and unloading of CPAs in tissues and tissue engineered equivalents and to reduce the time of contact between potentially toxic CPAs and tissues prior to and after the freezing process.
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M3 - Conference article
AN - SCOPUS:0034511417
SN - 0090-6964
VL - 28
SP - S-124
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - SUPPL. 1
T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society
Y2 - 12 October 2000 through 14 October 2000
ER -