Determination of erythrocyte fragility as a marker of pesticide-induced membrane oxidative damage

Bechan Sharma, Devendra K. Rai, Prashant Kumar Rai, S. I. Rizvi, Geeta Watal

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Erythrocytes are readily available cells and a good model system to study the health status of individuals with pathologic complications. It can also serve as a meaningful target to study toxicant/xenobioticinduced damages. We have prepared different concentrations of a carbamate pesticide (carbofuran) and carried out experiments to determine its toxicity on erythrocytes in terms of mean erythrocyte fragility (MEF). We observed a significant alteration in the osmotic fragility upon treatment with carbofuran. In our earlier studies we have observed a good correlation between OF and OS in diabetic subjects. Study reveals OF as a potential biomarker of oxidative membrane damage in pathologic conditions as well as toxicant/xenobiotic/pesticide-induced oxidative membrane damage to erythrocytes.

Original languageEnglish (US)
Title of host publicationAdvanced Protocols in Oxidative Stress II
PublisherHumana Press Inc.
Pages123-128
Number of pages6
ISBN (Print)9781607614104
DOIs
StatePublished - 2010

Publication series

NameMethods in Molecular Biology
Volume594
ISSN (Print)1064-3745

Keywords

  • Diabetes
  • Erythrocyte
  • Osmotic fragility
  • Xenobiotics

Fingerprint Dive into the research topics of 'Determination of erythrocyte fragility as a marker of pesticide-induced membrane oxidative damage'. Together they form a unique fingerprint.

Cite this