Determination of Aerobic Capacity via Cycle Ergometer Exercise Testing in Alzheimer’s Disease

Ulf G. Bronas, Dereck Salisbury, Kaitlin Kelly, Arthur Leon, Lisa Chow, Fang Yu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Older adults with Alzheimer’s disease (AD) may be unable to perform treadmill testing due to balance issues. We investigated whether older adults with AD could successfully complete a peak cycle ergometer test. Methods: Peak oxygen consumption (peak (Formula presented.)) assessed via a cycle ergometer test in 44 participants with AD (age 78.4 ± 6.8). Physical function was assessed via the incremental shuttle walk, 6-minute walk, and the Short Physical Performance Battery (SPPB). Results: All participants completed the cycle ergometer test successfully. Peak (Formula presented.) was correlated with SPPB (r =.35, P =.023), shuttle walk (r =.35, P =.024), 6-minute walk (r =.31, P =.05), and inversely with age (r = −.4, P =.009). There was no correlation between peak (Formula presented.) and cognition. Conclusion: Older adults with AD are able to safely complete a peak cycle ergometer exercise testing protocol. We provide an individualized cycle ergometer test for determining aerobic capacity in older adults with AD who may be unable to perform treadmill testing due to balance or gait issues.

Original languageEnglish (US)
Pages (from-to)500-508
Number of pages9
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Volume32
Issue number8
DOIs
StatePublished - Dec 1 2017

Bibliographical note

Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by National Institutes of Health National Institute on Aging award number R01AG043392 (Yu). Trials registration (NCT01954550). The CTSI were supported by the National Institutes of Health National Center for Advancing Translational Sciences (UL1TR000114).

Publisher Copyright:
© 2017, © The Author(s) 2017.

Keywords

  • Alzheimer’s disease
  • aging
  • cardiorespiratory fitness
  • cycle ergometer
  • dementia
  • physical function

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