Determinants of trafficking, conduction, and disease within a K⁺ channel revealed through multiparametric deep mutational scanning

Keyphrases

• Allosteric Ligands 33%
• Amino Acids 33%
• Clinical Genetics 33%
• Clinical Practice 33%
• Clinical Variant Interpretation 33%
• Control Signal 33%
• Deep mutational Scanning 100%
• Disease Mechanisms 33%
• Effect Database 33%
• Fitness Evaluation 33%
• Folding Stability 33%
• Function Model 33%
• Genetic Disease 33%
• High-resolution 33%
• Inward Rectifier Potassium Channel 33%
• Ion Conduction 33%
• K Channels 100%
• Kir2.1 100%
• Missense mutation 33%
• Multi-parameter 100%
• Pathogenic mutations 33%
• Pathogenicity 33%
• Promising Strategies 33%
• Protein Function 33%
• Protein Science 33%
• Protein Structure 33%
• Quality Control 33%
• Quantitative Model 33%
• Sequence-function Relationship 33%
• Sequence-structure Relationship 33%
• Structure Function 33%
• Surface Trafficking 33%
• Unknown Diseases 33%
• Variant Effect 66%
• Variants of Uncertain Significance 33%

Biochemistry, Genetics and Molecular Biology

• Allosteric Regulation 33%
• Amino Acids 33%
• Genetic Disorder 33%
• Genetics 33%
• Inward-Rectifier Potassium Ion Channel 33%
• Kir2.1 100%
• Missense Mutation 33%
• Potassium Channel 100%
• Protein Structure 33%
• Quality Control 33%
• Structure Activity Relation 33%
• Surface Property 33%