Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors

Rohini Chakravarthy, Sarah C. Stallings, Digna R. Velez Edwards, Sifang Kathy Zhao, Douglas Conway, J. Sunil Rao, Melinda C. Aldrich, Erin Kobetz, Consuelo H. Wilkins

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Collecting social determinants of health in electronic health records is time-consuming. Meanwhile, an Area Deprivation Index (ADI) aggregates sociodemographic information from census data. The objective of this study was to ascertain whether ADI is associated with stage of human papillomavirus (HPV)-related cancer at diagnosis. Methods: We tested for the association between the stage of HPV-related cancer presentation and ADI as well as the association between stage and the value of each census-based measure using ordered logistic regression, adjusting for age, race and sex. Results: Among 3247 cases of HPV-related cancers presenting to an urban academic medical center, the average age at diagnosis was 57. The average stage at diagnosis was Surveillance, Epidemiology and End Results Stage 3. In the study population, 43% of patients were female and 87% were white. In this study population, there was no association between stage of HPV-related cancer presentation and either aggregate or individual census variables. Conclusions: These results may reflect insufficient sample size, a lack of socio-demographic diversity in our population, or suggest that simplifying social determinants of health into a single geocoded index is not a reliable surrogate for assessing a patient's risk for HPV-related cancer.

Original languageEnglish (US)
Pages (from-to)18-27
Number of pages10
JournalJournal of Public Health
Issue number1
StatePublished - Mar 1 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Faculty of Public Health.


  • cancer
  • race
  • social determinants


Dive into the research topics of 'Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors'. Together they form a unique fingerprint.

Cite this