Determinants of radial artery pulse wave analysis in asymptomatic individuals

Daniel Duprez, Daniel R. Kaiser, Wayne Whitwam, Stanley M Finkelstein, Andres Belalcazar, Robert P Patterson, Stephen Glasser, Jay N Cohn

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background Noninvasive techniques to evaluate arterial stiffness include noninvasive radial artery pulse contour analysis. Diastolic pulse contour analysis provides a separate assessment of large (C1) and small artery (C2) elasticity. Analysis of the systolic pulse contour identifies two pressure peaks (P1 and P2) that relate to incident and reflected waves. This study aimed to compare indices from systolic and diastolic pulse contour analysis from the radial pressure waveform and to correlate these indices with traditional risk factors in asymptomatic individuals screened for cardiovascular disease. Methods In 298 consecutive subjects (206 male and 92 female healthy subjects with a mean age of 50 ± 12 years), noninvasive radial artery pressure waveforms were acquired with a piezoelectric transducer and analyzed for 1) diastolic indices of C1 and C2 from the CR-2000 CVProfiler, and 2) systolic indices of augmentation as defined by augmentation pressure (AP), augmentation index (AIx), and systolic reflective index (SRI = P2/P1). These indices were then correlated to each other as well as to individual traditional risk factors and the Framingham Risk Score. Results Diastolic indices were significantly and inversely correlated to systolic indices with C2 showing a stronger inverse association than C1. C2 and Alx were significantly correlated with height, weight, and body mass index in men but not in women. All indices correlated better to blood pressure in women than men. In women, only systolic indices were significantly correlated to HDL cholesterol and only diastolic indices were significantly correlated to LDL cholesterol. All indices were significantly correlated to the Framingham Risk Score, which was stronger in women then men, but when adjusted for age only diastolic indices remained significant in women. Conclusions Diastolic and systolic indices of pulse contour analysis correlate differently with traditional risk factors in men and women.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
JournalAmerican Journal of Hypertension
Volume17
Issue number8
DOIs
StatePublished - Aug 1 2004

Fingerprint

Pulse Wave Analysis
Radial Artery
Pulse
Pressure
Vascular Stiffness
Elasticity
Transducers
LDL Cholesterol
HDL Cholesterol
Healthy Volunteers
Body Mass Index
Cardiovascular Diseases
Arteries
Blood Pressure
Weights and Measures

Keywords

  • Pulse wave analysis
  • arterial stiffness
  • augmentation index
  • blood pressure
  • large and small artery elasticity index
  • radial artery
  • systolic reflective index

Cite this

Determinants of radial artery pulse wave analysis in asymptomatic individuals. / Duprez, Daniel; Kaiser, Daniel R.; Whitwam, Wayne; Finkelstein, Stanley M; Belalcazar, Andres; Patterson, Robert P; Glasser, Stephen; Cohn, Jay N.

In: American Journal of Hypertension, Vol. 17, No. 8, 01.08.2004, p. 647-653.

Research output: Contribution to journalArticle

Duprez, Daniel ; Kaiser, Daniel R. ; Whitwam, Wayne ; Finkelstein, Stanley M ; Belalcazar, Andres ; Patterson, Robert P ; Glasser, Stephen ; Cohn, Jay N. / Determinants of radial artery pulse wave analysis in asymptomatic individuals. In: American Journal of Hypertension. 2004 ; Vol. 17, No. 8. pp. 647-653.
@article{141ab93efb5c495c9d0dcdd5fe9aaab8,
title = "Determinants of radial artery pulse wave analysis in asymptomatic individuals",
abstract = "Background Noninvasive techniques to evaluate arterial stiffness include noninvasive radial artery pulse contour analysis. Diastolic pulse contour analysis provides a separate assessment of large (C1) and small artery (C2) elasticity. Analysis of the systolic pulse contour identifies two pressure peaks (P1 and P2) that relate to incident and reflected waves. This study aimed to compare indices from systolic and diastolic pulse contour analysis from the radial pressure waveform and to correlate these indices with traditional risk factors in asymptomatic individuals screened for cardiovascular disease. Methods In 298 consecutive subjects (206 male and 92 female healthy subjects with a mean age of 50 ± 12 years), noninvasive radial artery pressure waveforms were acquired with a piezoelectric transducer and analyzed for 1) diastolic indices of C1 and C2 from the CR-2000 CVProfiler, and 2) systolic indices of augmentation as defined by augmentation pressure (AP), augmentation index (AIx), and systolic reflective index (SRI = P2/P1). These indices were then correlated to each other as well as to individual traditional risk factors and the Framingham Risk Score. Results Diastolic indices were significantly and inversely correlated to systolic indices with C2 showing a stronger inverse association than C1. C2 and Alx were significantly correlated with height, weight, and body mass index in men but not in women. All indices correlated better to blood pressure in women than men. In women, only systolic indices were significantly correlated to HDL cholesterol and only diastolic indices were significantly correlated to LDL cholesterol. All indices were significantly correlated to the Framingham Risk Score, which was stronger in women then men, but when adjusted for age only diastolic indices remained significant in women. Conclusions Diastolic and systolic indices of pulse contour analysis correlate differently with traditional risk factors in men and women.",
keywords = "Pulse wave analysis, arterial stiffness, augmentation index, blood pressure, large and small artery elasticity index, radial artery, systolic reflective index",
author = "Daniel Duprez and Kaiser, {Daniel R.} and Wayne Whitwam and Finkelstein, {Stanley M} and Andres Belalcazar and Patterson, {Robert P} and Stephen Glasser and Cohn, {Jay N}",
year = "2004",
month = "8",
day = "1",
doi = "10.1016/j.amjhyper.2004.03.671",
language = "English (US)",
volume = "17",
pages = "647--653",
journal = "American Journal of Hypertension",
issn = "0895-7061",
number = "8",

}

TY - JOUR

T1 - Determinants of radial artery pulse wave analysis in asymptomatic individuals

AU - Duprez, Daniel

AU - Kaiser, Daniel R.

AU - Whitwam, Wayne

AU - Finkelstein, Stanley M

AU - Belalcazar, Andres

AU - Patterson, Robert P

AU - Glasser, Stephen

AU - Cohn, Jay N

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Background Noninvasive techniques to evaluate arterial stiffness include noninvasive radial artery pulse contour analysis. Diastolic pulse contour analysis provides a separate assessment of large (C1) and small artery (C2) elasticity. Analysis of the systolic pulse contour identifies two pressure peaks (P1 and P2) that relate to incident and reflected waves. This study aimed to compare indices from systolic and diastolic pulse contour analysis from the radial pressure waveform and to correlate these indices with traditional risk factors in asymptomatic individuals screened for cardiovascular disease. Methods In 298 consecutive subjects (206 male and 92 female healthy subjects with a mean age of 50 ± 12 years), noninvasive radial artery pressure waveforms were acquired with a piezoelectric transducer and analyzed for 1) diastolic indices of C1 and C2 from the CR-2000 CVProfiler, and 2) systolic indices of augmentation as defined by augmentation pressure (AP), augmentation index (AIx), and systolic reflective index (SRI = P2/P1). These indices were then correlated to each other as well as to individual traditional risk factors and the Framingham Risk Score. Results Diastolic indices were significantly and inversely correlated to systolic indices with C2 showing a stronger inverse association than C1. C2 and Alx were significantly correlated with height, weight, and body mass index in men but not in women. All indices correlated better to blood pressure in women than men. In women, only systolic indices were significantly correlated to HDL cholesterol and only diastolic indices were significantly correlated to LDL cholesterol. All indices were significantly correlated to the Framingham Risk Score, which was stronger in women then men, but when adjusted for age only diastolic indices remained significant in women. Conclusions Diastolic and systolic indices of pulse contour analysis correlate differently with traditional risk factors in men and women.

AB - Background Noninvasive techniques to evaluate arterial stiffness include noninvasive radial artery pulse contour analysis. Diastolic pulse contour analysis provides a separate assessment of large (C1) and small artery (C2) elasticity. Analysis of the systolic pulse contour identifies two pressure peaks (P1 and P2) that relate to incident and reflected waves. This study aimed to compare indices from systolic and diastolic pulse contour analysis from the radial pressure waveform and to correlate these indices with traditional risk factors in asymptomatic individuals screened for cardiovascular disease. Methods In 298 consecutive subjects (206 male and 92 female healthy subjects with a mean age of 50 ± 12 years), noninvasive radial artery pressure waveforms were acquired with a piezoelectric transducer and analyzed for 1) diastolic indices of C1 and C2 from the CR-2000 CVProfiler, and 2) systolic indices of augmentation as defined by augmentation pressure (AP), augmentation index (AIx), and systolic reflective index (SRI = P2/P1). These indices were then correlated to each other as well as to individual traditional risk factors and the Framingham Risk Score. Results Diastolic indices were significantly and inversely correlated to systolic indices with C2 showing a stronger inverse association than C1. C2 and Alx were significantly correlated with height, weight, and body mass index in men but not in women. All indices correlated better to blood pressure in women than men. In women, only systolic indices were significantly correlated to HDL cholesterol and only diastolic indices were significantly correlated to LDL cholesterol. All indices were significantly correlated to the Framingham Risk Score, which was stronger in women then men, but when adjusted for age only diastolic indices remained significant in women. Conclusions Diastolic and systolic indices of pulse contour analysis correlate differently with traditional risk factors in men and women.

KW - Pulse wave analysis

KW - arterial stiffness

KW - augmentation index

KW - blood pressure

KW - large and small artery elasticity index

KW - radial artery

KW - systolic reflective index

UR - http://www.scopus.com/inward/record.url?scp=4143109042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4143109042&partnerID=8YFLogxK

U2 - 10.1016/j.amjhyper.2004.03.671

DO - 10.1016/j.amjhyper.2004.03.671

M3 - Article

C2 - 15288881

AN - SCOPUS:4143109042

VL - 17

SP - 647

EP - 653

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 8

ER -