Determinants of Rad21 localization at the centrosome in human cells

Juan F. Giménez-Abián, Laura A. Díaz-Martínez, Nicole A. Beauchene, Wei Shan Hsu, Hung Ji Tsai, Duncan J. Clarke

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.

Original languageEnglish (US)
Pages (from-to)1759-1763
Number of pages5
JournalCell Cycle
Volume9
Issue number9
DOIs
StatePublished - May 1 2010

Bibliographical note

Funding Information:
We thank R. Kuriyama for ongoing discussions throughout the project and for critical reading of the manuscript. We thank K. Sullivan, S. Doxsey, S. Jensen, J. Peters and H. Yu for reagents. L.A.D.M. was partially funded by CONACyT, J.F.G.A. by BFU2008-03579/BMC, and D.J.C. by a seed grant from the University of Minnesota Academic Health Center.

Keywords

  • Centrin
  • Centriole
  • Centrosome
  • Cohesin
  • Mcd1
  • Rad21
  • Scc1
  • Smc1
  • Smc3
  • Spindle

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