Determinants of increased drug self-administration due to food deprivation

Marilyn E. Carroll, Richard A. Meisch

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Changes in oral etonitazene self-administration were compared in four groups of rats that were maintained at 100, 95, 85, or 75% of their pre-experimental free-feeding body weights. Etonitazene (5 μg/ml) or water was available for 16 h according to a fixed-ratio (FR) 1 schedule. Each liquid delivery (0.1 ml) was contingent upon a lever-press response. During food deprivation etonitazene intake gradually increased to over two-fold as body weights decreased over 25 sessions; etonitazene intake was inversely proportional to body weight. The 75% weight group showed stereotypy, self-mutilation and large variability in daily etonitazene intake. In another experiment a range of deprivation conditions was studied in a group of six rats with etonitazene (5 μg/ml) or water available on an FR 8 schedule during 1-h sessions. When the rats were gradually food satiated, etonitazene-maintained behavior declined but remained higher than water-maintained behavior; however, when they were abruptly food satiated, etonitazene-maintained behavior decreased to low levels.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalPsychopharmacology
Volume74
Issue number3
DOIs
StatePublished - Jul 1 1981

Keywords

  • Drug self-administration
  • Etonitazene
  • Food deprivation
  • Rats

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