Determinants in the measurement of pulmonary extravascular water

E. W. Humphrey, W. G. Lindsay, W. R. Murphy, L. Schwartz

Research output: Contribution to journalArticlepeer-review


The indicator dilution method for pulmonary extravascular water, utilizing 125I iodoantipyrine and 131I RISA, accurately measured in isolated, perfused dog lungs, a change in water volume of up to a 100% increase. The same technique in vivo measured 63% of the total weighed water in normal dogs and up to 92% in dogs undergoing hemorrhagic shock and retransfusion. This probably represents a change in the percent of perfused lung capillaries since there was no change in weighed water. Within a 2 hr period the fraction of lung capillaries perfused is not influenced by ventilation with 100% O2 or by atelectasis of the left lower lobe. The recruitment of pulmonary capillaries which occurs during and following hemorrhagic shock is partially blocked by isoproterenol and methylprednisolone. It is abetted by phenoxybenzamine.

Original languageEnglish (US)
Pages (from-to)132-141
Number of pages10
Issue number2
StatePublished - 1974


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