Detection of the early negative response in fMRI at 1.5 tesla

E. Yacoub, Xiaoping Hu

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Recent experimental studies have revealed an initial decrease in magnetic resonance (MR) signal that is consistent with optical imaging results. This initial response, thought to arise from a transient increase in deoxyhemoglobin concentration, is probably more localized to the site of neuronal activation. However, with MR imaging, this early response has only been demonstrated at high fields. In this paper, the observation of the initial response at 1.5 T is reported. Compared with results obtained at 4 T, the present study reveals that the initial response grows more rapidly with the field strength than the late positive response, suggesting a more microvascular origin of the initial response.

Original languageEnglish (US)
Pages (from-to)1088-1092
Number of pages5
JournalMagnetic resonance in medicine
Issue number6
StatePublished - 1999


  • BOLD
  • Early response
  • fMRI


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