Detection of 13C-labeled metabolites in the in vivo canine heart by B1 insensitive heteronuclear coherent polarization transfer and comparison of signal enhancement with NOE

Haoran Wei, Hellmut Merkle, Ya Xu, Jutta M Ellermann, Kevin Sipprell, Kamil Ugurbil

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4 Scopus citations

Abstract

A recently developed adiabatic coherent polarization transfer enhancement technique [H. Merkle, H. Wel, M. Garwood, K. Ugurhil. J. Magn. Reson. 99, 480-494 (1992)] was employed to perform 13C spectroscopy in the intact canine heart in vive during [2-13C]-acetate infusion into the left descending coronary artery; the results were compared with 13C spectra obtained with conventionally employed nuclear Overhauser enhancement. The results demonstrate that both methods can be performed by using surface coils to obtain in vive 13C spectra and that coherent polarization transfer provides better enhancement than NOE for [2-13C]-acetate but not for short T2 compounds.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalMagnetic resonance in medicine
Volume37
Issue number3
DOIs
StatePublished - Mar 1997

Keywords

  • acetate
  • glutamate
  • myocardium
  • tricarboxylic acid cycle

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