Detection of structural and functional changes in biological materials using angle-resolved low coherence interferometry

Kevin J. Chalut, Julie H. Ostrander, Adam Wax

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A well-established method of assessing structure is inverse light scattering analysis. With inverse light scattering analysis, the measured scattering properties of a scatterer(s) are associated with the most probable scattering distribution predicted by an appropriate light scattering model. One commonly used light scattering model is Mie theory, the electromagnetic theory of spherical scattering. Although Mie theory is a spherical scattering model, it has been used for deducing the geometry of spheroidal scatterers, which are important for studies of biological cell structure. The angle-resolved low coherence interferometry (a/LCI) technique is one method of Mie theory - based inverse light scattering analysis that has been used to evaluate biological structure both ex vivo and in vitro. In the present study, we examine the ability of a/LCI to assess structure, geometry, and cellular organization in ways that will further enable the study of function in biological materials.

Original languageEnglish (US)
Title of host publicationBiomedical Applications of Light Scattering II
StatePublished - Apr 21 2008
EventBiomedical Applications of Light Scattering II - San Jose, CA, United States
Duration: Jan 19 2008Jan 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherBiomedical Applications of Light Scattering II
Country/TerritoryUnited States
CitySan Jose, CA


  • Apoptosis
  • Cell function
  • Continuous nanostructures
  • Fractal dimension
  • Inverse light scattering analysis
  • Mie theory
  • Structure


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