TY - JOUR
T1 - Detection of preclinical parkinson disease in at-risk family members with use of [123I]-CIT and SPECT
T2 - An exploratory study
AU - Maraganore, Demetrius M.
AU - O'Connor, Michael K.
AU - Bower, James H.
AU - Kuntz, Karen M.
AU - Mcüonnell, Shannon K.
AU - Schah, Daniel J.
AU - Rocca, Walter A.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Objective: To explore whether the radioligand 2carboxymethoxy-3-(4-[123I] iodophenyl) tropane ([123I]CIT) and single-photon emission computed tomography (SPECT) can detect decreased striatal uptake in at-risk relatives of patients with Parkinson disease (PD). Patients and Methods: Ten PD patients, 10 at-risk first-degree relatives of PD patients, and 10 controls underwent [123I]-CIT and SPECT brain imaging. Their striatal uptake ratios were compared. Results: Age-adjusted specific to nonspecific striatal uptake ratios were lower in patients compared with controls and with relatives; however, ratios were similar in relatives and controls. Among relatives, ratios were consis-tently lower in subgroups postulated to be at higher risk for preclinical PD. Conclusion: Our findings provide preliminary support that [123I]β-CIT and SPECT may detect decreased striatal uptake in relatives of PD patients postulated to be at higher risk for PD.
AB - Objective: To explore whether the radioligand 2carboxymethoxy-3-(4-[123I] iodophenyl) tropane ([123I]CIT) and single-photon emission computed tomography (SPECT) can detect decreased striatal uptake in at-risk relatives of patients with Parkinson disease (PD). Patients and Methods: Ten PD patients, 10 at-risk first-degree relatives of PD patients, and 10 controls underwent [123I]-CIT and SPECT brain imaging. Their striatal uptake ratios were compared. Results: Age-adjusted specific to nonspecific striatal uptake ratios were lower in patients compared with controls and with relatives; however, ratios were similar in relatives and controls. Among relatives, ratios were consis-tently lower in subgroups postulated to be at higher risk for preclinical PD. Conclusion: Our findings provide preliminary support that [123I]β-CIT and SPECT may detect decreased striatal uptake in relatives of PD patients postulated to be at higher risk for PD.
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U2 - 10.4065/74.7.681
DO - 10.4065/74.7.681
M3 - Article
C2 - 10405696
AN - SCOPUS:0032989409
VL - 74
SP - 681
EP - 685
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 7
ER -