Detection of patients with hypertrophic cardiomyopathy at risk for paroxysmal atrial fibrillation during sinus rhythm by P-wave dispersion

Sedat Köse, Kudret Aytemir, Elif Sade, Ilknur Can, Necla Özer, Basri Amasyali, Serdar Aksöyek, Kenan Övüç, Ferhan Özmen, Enver Atalar, Ersoy Isi̧k, Sirri Kes, Ertan Demirtaş, Ali Oto

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Background: Paroxysmal atrial fibrillation (PAF) in hypertrophic cardiomyopathy (HCM) is associated with poor prognosis. Previous studies have shown good correlation between P-wave dispersion (Pd) and occurrence of PAF. However, Pd in patients with HCM for predicting PAF has not been studied. Hypothesis: The aim of the study was to determine whether Pd could identify patients with HCM who are likely to suffer from PAF. Methods: Twenty-two patients with HCM with a history of PAF (Group 1) and 26 patients with HCM without a history of PAF (Group 2) were studied. Maximum (Pmax) and minimum (Pmin) P-wave durations, as well as P-wave dispersion (Pd = Pmax - Pmin) were calculated from 12-lead surface electrocardiograms (ECG). Results: P-wave dispersion was significantly different between the groups (Group 1: 55 ± 6 ms vs. Group 2: 37 ± 8 ms; p < 0.001), while Pmax (Group 1: 134 ± 11 ms vs. Group 2: 128 ± 13 ms; p = 0.06) and Pmin (Group 1: 78 ± 9 ms vs. Group 2: 81 ± 7 ms; p = 0.07) was not significantly different. Patients with a history of PAF had higher left atrial diameter than the patients without PAF (Group 1: 52 ± 8 mm vs. Group 2:48 ± 10 mm; p = 0.02). A cut-off value of 46 ms for Pd had a sensitivity of 76% and a specificity of 82% in discriminating between patients with and without PAF. Conclusion: This study suggests that P-wave dispersion could identify patients with HCM who are likely to develop PAF.

Original languageEnglish (US)
Pages (from-to)431-434
Number of pages4
JournalClinical Cardiology
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2003

Keywords

  • Atrial fibrillation
  • Hypertrophic cardiomyopathy
  • P-wave dispersion

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