Abstract
In January 2017, the World Health Organisation recommended the Xpert® MTB/RIF Ultra assay (Ultra) for tuberculosis (TB) diagnosis. Ultra offers improved analytical sensitivity when compared with the initial Xpert® MTB/RIF (Xpert) assay for the detection of Mycobacterium tuberculosis. Ultra is therefore likely to be of particular benefit for detecting paucibacillary TB. We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB. This represents the first published instance of a diagnosis of extrapulmonary TB made on the basis of a positive urine Ultra assay. The use of Ultra on urine may be a useful addition to the diagnostic armamentarium for disseminated TB in persons with HIV co-infection. The diagnostic accuracy of urine Ultra should be characterised further via prospective studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 92-94 |
| Number of pages | 3 |
| Journal | International Journal of Infectious Diseases |
| Volume | 75 |
| DOIs | |
| State | Published - Oct 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Authors
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Mycobacterium tuberculosis
- Renal tuberculosis
- Urine
- Xpert MTB/RIF Ultra
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