Detection of Kaposi's sarcoma-associated herpesvirus in oral and genital secretions of Zimbabwean women

Thomas M. Lampinen, Shalini Kulasingam, Min Juno, Margaret Borok, Lovemore Gwanzura, Julie Lamb, Kassam Mahomed, Godfrey B. Woelk, Kurt B. Strand, Marnix L. Bosch, Daniel C. Edelman, Niel T. Constantine, David Katzenstein, Michelle A. Williams

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Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) in oral and genital secretions of women may be involved in horizontal and vertical transmission in endemic regions. Nested polymerse chain reaction assays were used to detect KSHV DNA sequences in one-third of oral, vaginal, and cervical specimens and in 42% of peripheral blood mononuclear cell (PBMC) specimens collected from 41 women infected with human immunodeficiency virus type 1 who had Kaposi's sarcoma (KS). KSHV DNA was not detected in specimens from 100 women without KS, 9 of whom were seropositive for KSHV. A positive association was observed between KSHV DNA detection in oral and genital mucosa, neither of which was associated with KSHV DNA detection in PBMC. These data suggest that KSHV replicates in preferred anatomic sites at levels independent of PBMC viremia. Detection of genital-tract KSHV only among relatively immunosuppressed women may provide an explanation for infrequent perinatal transmission of KSHV.

Original languageEnglish (US)
Pages (from-to)1785-1790
Number of pages6
JournalJournal of Infectious Diseases
Volume181
Issue number5
DOIs
StatePublished - 2000

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    Lampinen, T. M., Kulasingam, S., Juno, M., Borok, M., Gwanzura, L., Lamb, J., Mahomed, K., Woelk, G. B., Strand, K. B., Bosch, M. L., Edelman, D. C., Constantine, N. T., Katzenstein, D., & Williams, M. A. (2000). Detection of Kaposi's sarcoma-associated herpesvirus in oral and genital secretions of Zimbabwean women. Journal of Infectious Diseases, 181(5), 1785-1790. https://doi.org/10.1086/315426