Abstract
Eighty breast cancer specimens were examined for insulin-like growth factor binding protein (IGFBP) expression by ligand blotting. Five distinct IGFBP species were found: a doublet at 48 and 44 kDa was IGFBP-3, the 34-kDa band was IGFBP-2, and a band at 24 kDa was IGFBP-4. A 32-kDa band was compatible with the migration position reported for IGFBP-5. IGFBP-3 was inversely correlated with ER expression, while IGFBP-4 was positively correlated with both ER and PgR. IGFBP-4 was also inversely correlated with S-phase fraction. Thus, IGFBP expression correlates with other parameters of breast cancer biology and may play a role in regulating tumor growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Cancer Letters |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 28 1994 |
Bibliographical note
Funding Information:Douglas Yee is a Pew Scholar in the Biomedical Sciencesa nd recipient of an NIH Research Career Development Award. This work was supported by grants R29 CA52592 and PO1 CA30195 and a cancer center support grant to the Cancer Therapy and Research Center. Jose A. Figueroa is supported by an NRSA training grant, CA09434.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Breast cancer
- Estrogen receptor
- Insulin-like growth factor binding proteins
- Progesterone receptor
- S-phase fraction
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