Detection of Early Progression with 18F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy

Mark C. Markowski; Pedro Isaacsson Velho; Mario A. Eisenberger; Martin G. Pomper; Kenneth J. Pienta; Michael A. Gorin; Emmanuel S. Antonarakis; Samuel R. Denmeade; Steven P. Rowe

doi:10.2967/jnumed.120.259226

Detection of Early Progression with ¹⁸F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy

Mark C. Markowski
, Pedro Isaacsson Velho
, Mario A. Eisenberger
, Martin G. Pomper
, Kenneth J. Pienta
, Michael A. Gorin
, Emmanuel S. Antonarakis
, Samuel R. Denmeade
, Steven P. Rowe

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Bipolar androgen therapy (BAT) is an emerging treatment for metastatic castration-resistant prostate cancer (mCRPC). ¹⁸F-DCFPyL is a small-molecule PET radiotracer targeting prostate-specific membrane antigen (PSMA). We analyzed the utility of ¹⁸F-DCFPyL PET/CT in determining clinical response to BAT. Methods: Six men with mCRPC receiving BAT were imaged with ¹⁸F-DCFPyL PET/CT at baseline and after 3 mo of treatment. Progression by PSMA-targeted PET/CT was defined as the appearance of any new ¹⁸F-DCFPyL–avid lesion. Results: Three of 6 (50%) patients had progression on ¹⁸F-DCFPyL PET/CT. All 3 had stable disease or better on contemporaneous conventional imaging. Radiographic progression on CT or bone scanning was observed within 3 mo of progression on ¹⁸F-DCFPyL PET/CT. For the 3 patients who did not have progression on ¹⁸F-DCFPyL PET/ CT, radiographic progression was not observed for at least 6 mo. Conclusion: New radiotracer-avid lesions on ¹⁸F-DCFPyL PET/CT in men with mCRPC undergoing BAT can indicate early progression.

Original language	English (US)
Pages (from-to)	1270-1273
Number of pages	4
Journal	Journal of Nuclear Medicine
Volume	62
Issue number	9
DOIs	https://doi.org/10.2967/jnumed.120.259226
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Keywords

PSMA
early progression
testosterone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.2967/jnumed.120.259226

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Cite this

Markowski, M. C., Velho, P. I., Eisenberger, M. A., Pomper, M. G., Pienta, K. J., Gorin, M. A., Antonarakis, E. S., Denmeade, S. R., & Rowe, S. P. (2021). Detection of Early Progression with ¹⁸F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy. Journal of Nuclear Medicine, 62(9), 1270-1273. https://doi.org/10.2967/jnumed.120.259226

Markowski, MC, Velho, PI, Eisenberger, MA, Pomper, MG, Pienta, KJ, Gorin, MA, Antonarakis, ES, Denmeade, SR & Rowe, SP 2021, 'Detection of Early Progression with ¹⁸F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy', Journal of Nuclear Medicine, vol. 62, no. 9, pp. 1270-1273. https://doi.org/10.2967/jnumed.120.259226

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title = "Detection of Early Progression with 18F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy",

abstract = "Bipolar androgen therapy (BAT) is an emerging treatment for metastatic castration-resistant prostate cancer (mCRPC). 18F-DCFPyL is a small-molecule PET radiotracer targeting prostate-specific membrane antigen (PSMA). We analyzed the utility of 18F-DCFPyL PET/CT in determining clinical response to BAT. Methods: Six men with mCRPC receiving BAT were imaged with 18F-DCFPyL PET/CT at baseline and after 3 mo of treatment. Progression by PSMA-targeted PET/CT was defined as the appearance of any new 18F-DCFPyL–avid lesion. Results: Three of 6 (50\%) patients had progression on 18F-DCFPyL PET/CT. All 3 had stable disease or better on contemporaneous conventional imaging. Radiographic progression on CT or bone scanning was observed within 3 mo of progression on 18F-DCFPyL PET/CT. For the 3 patients who did not have progression on 18F-DCFPyL PET/ CT, radiographic progression was not observed for at least 6 mo. Conclusion: New radiotracer-avid lesions on 18F-DCFPyL PET/CT in men with mCRPC undergoing BAT can indicate early progression.",

keywords = "PSMA, early progression, testosterone",

author = "Markowski, \{Mark C.\} and Velho, \{Pedro Isaacsson\} and Eisenberger, \{Mario A.\} and Pomper, \{Martin G.\} and Pienta, \{Kenneth J.\} and Gorin, \{Michael A.\} and Antonarakis, \{Emmanuel S.\} and Denmeade, \{Samuel R.\} and Rowe, \{Steven P.\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the Society of Nuclear Medicine and Molecular Imaging.",

year = "2021",

doi = "10.2967/jnumed.120.259226",

language = "English (US)",

volume = "62",

pages = "1270--1273",

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T1 - Detection of Early Progression with 18F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy

AU - Markowski, Mark C.

AU - Velho, Pedro Isaacsson

AU - Eisenberger, Mario A.

AU - Pomper, Martin G.

AU - Pienta, Kenneth J.

AU - Gorin, Michael A.

AU - Antonarakis, Emmanuel S.

AU - Denmeade, Samuel R.

AU - Rowe, Steven P.

PY - 2021

Y1 - 2021

N2 - Bipolar androgen therapy (BAT) is an emerging treatment for metastatic castration-resistant prostate cancer (mCRPC). 18F-DCFPyL is a small-molecule PET radiotracer targeting prostate-specific membrane antigen (PSMA). We analyzed the utility of 18F-DCFPyL PET/CT in determining clinical response to BAT. Methods: Six men with mCRPC receiving BAT were imaged with 18F-DCFPyL PET/CT at baseline and after 3 mo of treatment. Progression by PSMA-targeted PET/CT was defined as the appearance of any new 18F-DCFPyL–avid lesion. Results: Three of 6 (50%) patients had progression on 18F-DCFPyL PET/CT. All 3 had stable disease or better on contemporaneous conventional imaging. Radiographic progression on CT or bone scanning was observed within 3 mo of progression on 18F-DCFPyL PET/CT. For the 3 patients who did not have progression on 18F-DCFPyL PET/ CT, radiographic progression was not observed for at least 6 mo. Conclusion: New radiotracer-avid lesions on 18F-DCFPyL PET/CT in men with mCRPC undergoing BAT can indicate early progression.

AB - Bipolar androgen therapy (BAT) is an emerging treatment for metastatic castration-resistant prostate cancer (mCRPC). 18F-DCFPyL is a small-molecule PET radiotracer targeting prostate-specific membrane antigen (PSMA). We analyzed the utility of 18F-DCFPyL PET/CT in determining clinical response to BAT. Methods: Six men with mCRPC receiving BAT were imaged with 18F-DCFPyL PET/CT at baseline and after 3 mo of treatment. Progression by PSMA-targeted PET/CT was defined as the appearance of any new 18F-DCFPyL–avid lesion. Results: Three of 6 (50%) patients had progression on 18F-DCFPyL PET/CT. All 3 had stable disease or better on contemporaneous conventional imaging. Radiographic progression on CT or bone scanning was observed within 3 mo of progression on 18F-DCFPyL PET/CT. For the 3 patients who did not have progression on 18F-DCFPyL PET/ CT, radiographic progression was not observed for at least 6 mo. Conclusion: New radiotracer-avid lesions on 18F-DCFPyL PET/CT in men with mCRPC undergoing BAT can indicate early progression.

KW - PSMA

KW - early progression

KW - testosterone

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