Detection of dopamine neurotransmission in "real time"

Rajendra D. Badgaiyan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Current imaging techniques have limited ability to detect neurotransmitters released during brain processing. It is a critical limitation because neurotransmitters have significant control over the brain activity. In this context, recent development of single-scan dynamic molecular imaging technique is important because it allows detection, mapping, and measurement of dopamine released in the brain during task performance. The technique exploits the competition between endogenously released dopamine and its receptor ligand for occupancy of receptor sites. Dopamine released during task performance is detected by dynamically measuring concentration of intravenously injected radiolabeled ligand using a positron emission tomography (PET) camera. Based on the ligand concentration, values of receptor kinetic parameters are estimated. These estimates allow detection of dopamine released in the human brain during task performance.

Original languageEnglish (US)
Article numberArticle 125
JournalFrontiers in Neuroscience
Issue number7 JUL
DOIs
StatePublished - Jan 1 2013

Keywords

  • Cognition
  • Dopamine
  • Dynamic molecular imaging
  • Fallypride
  • Neurotransmitter imaging
  • Positron emission tomography
  • Raclopride

Fingerprint Dive into the research topics of 'Detection of dopamine neurotransmission in "real time"'. Together they form a unique fingerprint.

Cite this