Detecting drug interactions: A review of the literature

C. A. Jankel, S. M. Speedie, G. Rivera, C. Fiset

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

This article provides a historic overview of drug interaction screening and reviews 19 studies that have sought to measure the frequency of drug interactions. Differences in study designs, methodologies, and definition contribute a considerable variation in the reported incidence rates, which ranged from 2.2 to 70.3 percent for all potential drug interactions. The percentage of patients actually experiencing symptoms that could be attributed to a drug interaction, however, ranged from 0 to 11.1 percent. The relative importance of drug interactions as a clinical problem remains unclear. Screening programs that do more than simply identify large numbers of patients who receive potentially interacting drug combinations without indicating which subpopulations of these individuals are likely to be harmed by the drugs have not yet been developed.

Original languageEnglish (US)
Pages (from-to)982-989
Number of pages8
JournalDICP, Annals of Pharmacotherapy
Volume24
Issue number10
DOIs
StatePublished - 1990

Bibliographical note

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Detecting drug interactions: A review of the literature'. Together they form a unique fingerprint.

Cite this