Results of detached eddy simulations of the Reentry-F vehicle are presented and compared to the experimental data. Comparisons between the new DES model and a traditional RANS model show a substantial improvement in predicted base heating rates. A grid resolution study is performed to examine the sensitivity of the DES formulation to the grid spacing. It is shown that the grid is required to have approximately 3 times more cells in the base than its typical RANS counterpart in order to adequately capture the unsteady flow on the base. Initial results at zero angle of attack indicate a discrepancy with experiment which is accounted for by inclusion of a small experimentally measured angle of attack. Moreover, it is observed that the simulations are very sensitive to the vehicle orientation. Upon accounting for this sensitivity, the resulting predicted base pressure and heating are shown to be in very good agreement with the flight data, typically within the stated experimental uncertainty.