Abstract
Phosphoramidate pronucleotides have proven to be an effective strategy for the intracellular delivery of nucleoside 5′-monophosphates. This review will summarize our efforts to understand the in vitro and in vivo behavior of phosphoramidate monoesters of 3′-azido-3′-deoxythymidine (AZT), 3′ -fluoro-3′-deoxythymidine (FLT) and 5-fluoro-2′-deoxyuridine (FUdR). Insights drawn from these studies have proved valuable for the future design of phosphoramidate-based pronucleotides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 409-419 |
| Number of pages | 11 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 2004 |
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SDG 3 Good Health and Well-being
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