Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Dan P. Drontle, Carston R. Wagner

Research output: Contribution to journalReview article

66 Scopus citations


Phosphoramidate pronucleotides have proven to be an effective strategy for the intracellular delivery of nucleoside 5′-monophosphates. This review will summarize our efforts to understand the in vitro and in vivo behavior of phosphoramidate monoesters of 3′-azido-3′-deoxythymidine (AZT), 3′ -fluoro-3′-deoxythymidine (FLT) and 5-fluoro-2′-deoxyuridine (FUdR). Insights drawn from these studies have proved valuable for the future design of phosphoramidate-based pronucleotides.

Original languageEnglish (US)
Pages (from-to)409-419
Number of pages11
JournalMini-Reviews in Medicinal Chemistry
Issue number4
StatePublished - May 2004


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