Designer excipients enable oral delivery of poorly soluble drugs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Upon oral administration of active pharmaceutical ingredients, achieving adequate absorption for therapeutic effect remains a key challenge for the majority of pipeline drug candidates.1 This is attributed to poor water solubility of hydrophobic and often crystalline small drug molecules. Amorphous solid dispersions (ASDs) have emerged as viable nanomaterials to overcome intrinsic solubility limitations by supersaturating the drug in solution.2 However, preventing reprecipitation over pharmaceutically-relevant time scales mandates nanocarriers that can effectively stabilize amorphized drug molecules. Here, we employ a directed design approach to build libraries of tailored polymers as ASD excipients around the chemical structures of antiseizure and antiandrogen drugs, phenytoin and nilutamide, respectively. High-throughput synthesis and screening tools aided in the development of robust controlled delivery systems that maintained elevated drug concentrations and enhanced oral bioavailability metrics above reported studies to date.3.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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Keywords

  • Amorphous Solid Dispersions
  • Oral Drug Delivery
  • Pharmaceuticals
  • Polymers

Cite this

Ting, J. M., Bates, F. S., & Reineke, T. M. (2019). Designer excipients enable oral delivery of poorly soluble drugs. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.