Design, synthesis and docking studies of 2-benzoxazolinone-based 1,2,4-triazoles as proinflammatory cytokine inhibitors

Saqlain Haider, Mohammad Sarwar Alam, Hinna Hamid, Abhijeet Dhulap, Sadiq Umar, Mohammad Shahar Yar, Sameena Bano, Syed Nazreen, Yakub Ali, Chetna Kharbanda

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A library of 20 novel benzoxazolinone-based 1,2,4-triazoles has been synthesised and screened for their in vivo anti-inflammatory and antinociceptive activities. The compound 18e exhibited potent anti-inflammatory activity with 68.75 and 55.20 % inhibition in comparison to indomethacin which showed 65.62 and 60.41 % inhibition after 3 and 5 h, respectively. The five active compounds, i.e. 2a and 17e-20e showing significant in vivo anti-inflammatory activity have been screened for their in vivo COX-2, TNF-α, IL-1β and NO inhibitory activities. The COX-2 selectivity index of 17e was found to be 42.30 and thereby showing a high selectivity towards COX-2 inhibition. In silico molecular docking studies have been done in order to get an insight into the binding modes of these molecules with TNF-α protein. The compound 20e exhibited potent antinociceptive activity with 56.70 % inhibition of analgesia. The compounds 2a and 17e-20e did not exhibit any gastric ulceration.

Original languageEnglish (US)
Pages (from-to)4250-4268
Number of pages19
JournalMedicinal Chemistry Research
Volume23
Issue number9
DOIs
StatePublished - Aug 5 2014

Bibliographical note

Funding Information:
Acknowledgments The authors thank Dr. G. N. Qazi, Vice-Chancellor, Jamia Hamdard for providing necessary facilities to the Department of Chemistry. One of the authors (SH) is also thankful to CSIR for awarding the senior research fellowship.

Keywords

  • 2AZ5 ligand
  • Antinociceptive
  • Cyclooxygenase
  • Molecular docking

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