Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

S. Chandrasekhar; V. Jagadeshwar; Ch Narsihmulu; M. Sarangapani; D. R. Krishna; J. Vidyasagar; Dolly Vijay; G. Narahari Sastry

doi:10.1016/j.bmcl.2004.05.017

Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

S. Chandrasekhar, V. Jagadeshwar, Ch Narsihmulu, M. Sarangapani, D. R. Krishna, J. Vidyasagar, Dolly Vijay, G. Narahari Sastry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of β-tubulin.

Original language	English (US)
Pages (from-to)	3687-3689
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2004.05.017
State	Published - Jul 16 2004
Externally published	Yes

Bibliographical note

Funding Information:
V.J. and C.N.G. thank CSIR, New Delhi for the financial assistance. Research grants for the project from DST, New Delhi is acknowledged.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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title = "Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin",

abstract = "A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of β-tubulin.",

author = "S. Chandrasekhar and V. Jagadeshwar and Ch Narsihmulu and M. Sarangapani and Krishna, {D. R.} and J. Vidyasagar and Dolly Vijay and Sastry, {G. Narahari}",

note = "Funding Information: V.J. and C.N.G. thank CSIR, New Delhi for the financial assistance. Research grants for the project from DST, New Delhi is acknowledged. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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AU - Chandrasekhar, S.

AU - Jagadeshwar, V.

AU - Narsihmulu, Ch

AU - Sarangapani, M.

AU - Krishna, D. R.

AU - Vidyasagar, J.

AU - Vijay, Dolly

AU - Sastry, G. Narahari

N1 - Funding Information: V.J. and C.N.G. thank CSIR, New Delhi for the financial assistance. Research grants for the project from DST, New Delhi is acknowledged. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004/7/16

Y1 - 2004/7/16

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Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

Abstract

Bibliographical note

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