Design of ultra-low power biopotential amplifiers for biosignal acquisition applications

Fan Zhang, Jeremy Holleman, Brian P. Otis

Research output: Contribution to journalArticlepeer-review

213 Scopus citations


Rapid development in miniature implantable electronics are expediting advances in neuroscience by allowing observation and control of neural activities. The first stage of an implantable biosignal recording system, a low-noise biopotential amplifier (BPA), is critical to the overall power and noise performance of the system. In order to integrate a large number of front-end amplifiers in multichannel implantable systems, the power consumption of each amplifier must be minimized. This paper introduces a closed-loop complementary-input amplifier, which has a bandwidth of 0.05 Hz to 10.5 kHz, an input-referred noise of 2.2 μ V rms , and a power dissipation of 12 μ W. As a point of comparison, a standard telescopic-cascode closed-loop amplifier with a 0.4 Hz to 8.5 kHz bandwidth, input-referred noise of 3.2 μ V rms , and power dissipation of 12.5 μ W is presented. Also for comparison, we show results from an open-loop complementary-input amplifier that exhibits an input-referred noise of 3.6 μ V rms while consuming 800 nW of power. The two closed-loop amplifiers are fabricated in a 0.13 μ m CMOS process. The open-loop amplifier is fabricated in a 0.5 μ m SOI-BiCMOS process. All three amplifiers operate with a 1 V supply.

Original languageEnglish (US)
Article number6129415
Pages (from-to)344-355
Number of pages12
JournalIEEE transactions on biomedical circuits and systems
Issue number4
StatePublished - 2012
Externally publishedYes


  • Analog integrated circuits
  • biopotential amplifier
  • biosignal amplifier
  • low noise
  • low-power circuit design
  • neural amplifier
  • noise efficiency factor


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