Design of self-assembling protein-polymer conjugates

Nathan A Carter, Xi Geng, Tijana Z. Grove

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Protein-polymer conjugates are of particular interest for nanobiotechnology applications because of the various and complementary roles that each component may play in composite hybrid-materials. This chapter focuses on the design principles and applications of self-assembling protein- polymer conjugate materials. We address the general design methodology, from both synthetic and genetic perspective, conjugation strategies, protein vs. polymer driven self-assembly and finally, emerging applications for conjugate materials. By marrying proteins and polymers into conjugated bio-hybrid materials, materials scientists, chemists, and biologists alike, have at their fingertips a vast toolkit for material design. These inherently hierarchical structures give rise to useful patterning, mechanical and transport properties that may help realize new, more efficient materials for energy generation, catalysis, nanorobots, etc.

Original languageEnglish (US)
Pages (from-to)179-214
Number of pages36
JournalAdvances in Experimental Medicine and Biology
Volume940
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

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Keywords

  • Bio-hybrid materials
  • Conjugation strategies
  • Molecular-scale interactions
  • Nanostructural design
  • Proteinpolymer conjugates
  • Self-assembly

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