Design of organocatalysts for asymmetric direct syn-aldol reactions

Xiao Ying Xu, Yanzhao Wang, Liu Zhu Gong

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-β-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities of up to 99% ee.

Original languageEnglish (US)
Pages (from-to)4247-4249
Number of pages3
JournalOrganic Letters
Issue number21
StatePublished - Oct 11 2007


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