Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies

Arun K. Ghosh, Cuthbert D. Martyr, Heather L. Osswald, Venkat Reddy Sheri, Luke A. Kassekert, Shujing Chen, Johnson Agniswamy, Yuan Fang Wang, Hironori Hayashi, Manabu Aoki, Irene T. Weber, Hiroaki Mitsuya

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science