Design of a 13C {1H} RF Probe for monitoring the in vivo metabolism of [1-13C]glucose in primate brain

B. E. Hammer; W. Sacks; R. E. Bigler; M. J. Hennessy; S. Sacks; A. Fleischer; P. B. Zanzonico

doi:10.1002/mrm.1910130102

Design of a ¹³C {¹H} RF Probe for monitoring the in vivo metabolism of [1-¹³C]glucose in primate brain

B. E. Hammer, W. Sacks, R. E. Bigler, M. J. Hennessy, S. Sacks, A. Fleischer, P. B. Zanzonico

Radiology

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Abstract

The design of an RF probe suitable for obtaining proton-decoupled ¹³C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of ¹³C and the other to the resonant frequency of ¹H, were used to monitor the in vivo metabolism of [1-¹³C]glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of ¹³C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of [1-¹³C]glucose.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/mrm.1910130102
State	Published - Jan 1 1990

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title = "Design of a 13C {1H} RF Probe for monitoring the in vivo metabolism of [1-13C]glucose in primate brain",

abstract = "The design of an RF probe suitable for obtaining proton-decoupled 13C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13C and the other to the resonant frequency of 1H, were used to monitor the in vivo metabolism of [1-13C]glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of [1-13C]glucose.",

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AU - Hammer, B. E.

AU - Sacks, W.

AU - Bigler, R. E.

AU - Hennessy, M. J.

AU - Sacks, S.

AU - Fleischer, A.

AU - Zanzonico, P. B.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The design of an RF probe suitable for obtaining proton-decoupled 13C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13C and the other to the resonant frequency of 1H, were used to monitor the in vivo metabolism of [1-13C]glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of [1-13C]glucose.

AB - The design of an RF probe suitable for obtaining proton-decoupled 13C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13C and the other to the resonant frequency of 1H, were used to monitor the in vivo metabolism of [1-13C]glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of [1-13C]glucose.

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Design of a ¹³C {¹H} RF Probe for monitoring the in vivo metabolism of [1-¹³C]glucose in primate brain

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