Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs

A. E. Jergens, R. B. Evans, M. Ackermann, J. Hostetter, M. Willard, J. Mansell, T. Bilzer, B. Wilcock, R. Washabau, E. J. Hall, T. Minami, C. Wang, M. J. Day

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Significant interobserver variability in the diagnostic interpretation of endoscopic gastrointestinal (GI) specimens exists even with the use of World Small Animal Veterinary Association (WSAVA) standardization criteria. Chi-square analyses compared the extent of pathologists' agreement for microarchitectural features of inflammation in endoscopic specimens obtained from 253 animals of the original WSAVA study. Patterns of agreement between pathologists were classified as broad (3/4 pathologists agreed), dichotomous (2/4 pathologists agreed), or divergent (no agreement between pathologists). The simplified model for GI inflammation was based on those parameters for which the pathologists had either broad or minimally divergent opinions of histopathologic significance. In this model, the parameters chosen were as follows: gastric parameters (intraepithelial lymphocytes [IELs], lamina propria [LP] infiltrates, and mucosal fibrosis), duodenal parameters (villus atrophy, epithelial injury, IELs, crypt changes, and LP infiltrates), and colonic parameters (epithelial injury, crypt dilation, fibrosis, LP infiltrates, and goblet cell depletion). Preliminary data using this simplified model showed excellent correlation between pathologists in defining the presence and extent of GI inflammation in dogs.

Original languageEnglish (US)
Pages (from-to)946-950
Number of pages5
JournalVeterinary pathology
Volume51
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

laminae (animals)
inflammation
Dogs
Inflammation
fibrosis
dogs
lymphocytes
animals
goblet cells
villi
Mucous Membrane
atrophy
standardization
stomach
Fibrosis
Lymphocytes
Goblet Cells
Observer Variation
Wounds and Injuries
Pathologists

Keywords

  • cat
  • digestive tract
  • disease process
  • dog
  • domestic mammals
  • gastrointestinal
  • imaging
  • immunologic/inflammation
  • morphometry
  • species
  • technology
  • tissue

Cite this

Jergens, A. E., Evans, R. B., Ackermann, M., Hostetter, J., Willard, M., Mansell, J., ... Day, M. J. (2014). Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs. Veterinary pathology, 51(5), 946-950. https://doi.org/10.1177/0300985813511123

Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs. / Jergens, A. E.; Evans, R. B.; Ackermann, M.; Hostetter, J.; Willard, M.; Mansell, J.; Bilzer, T.; Wilcock, B.; Washabau, R.; Hall, E. J.; Minami, T.; Wang, C.; Day, M. J.

In: Veterinary pathology, Vol. 51, No. 5, 01.01.2014, p. 946-950.

Research output: Contribution to journalArticle

Jergens, AE, Evans, RB, Ackermann, M, Hostetter, J, Willard, M, Mansell, J, Bilzer, T, Wilcock, B, Washabau, R, Hall, EJ, Minami, T, Wang, C & Day, MJ 2014, 'Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs', Veterinary pathology, vol. 51, no. 5, pp. 946-950. https://doi.org/10.1177/0300985813511123
Jergens AE, Evans RB, Ackermann M, Hostetter J, Willard M, Mansell J et al. Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs. Veterinary pathology. 2014 Jan 1;51(5):946-950. https://doi.org/10.1177/0300985813511123
Jergens, A. E. ; Evans, R. B. ; Ackermann, M. ; Hostetter, J. ; Willard, M. ; Mansell, J. ; Bilzer, T. ; Wilcock, B. ; Washabau, R. ; Hall, E. J. ; Minami, T. ; Wang, C. ; Day, M. J. / Design of a Simplified Histopathologic Model for Gastrointestinal Inflammation in Dogs. In: Veterinary pathology. 2014 ; Vol. 51, No. 5. pp. 946-950.
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