Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis

Keyphrases

• Mechanism-based Inhibitor 100%
• Pyridoxal 5′-phosphate 100%
• Biotin Biosynthesis 100%
• Aminotransferase 100%
• Michael Acceptor 100%
• Allylic Amines 100%
• In Situ 50%
• Chemical Stability 50%
• Enhanced Stability 50%
• Keto 50%
• Bicyclic Lactams 50%
• Aromatization 50%
• Michael Addition 50%
• Streptomyces Strains 50%
• Cyclic Analogs 50%
• Terminal Olefins 50%
• Horner-Wadsworth-Emmons Olefination 50%
• Overman Rearrangement 50%
• Warhead 50%
• Enzymatic Oxidation 50%
• Exocyclic Olefins 50%
• Common Strategies 50%
• Alkyne Zipper Reaction 50%

Chemistry

• Alkene 100%
• Michael Reaction 100%
• Biotin 100%
• Pyridoxal 100%
• Chemical Stability 50%
• Zipper Reaction 50%
• Michael Addition 50%
• Overman Rearrangement 50%
• Cofactor 50%
• Alkyne 50%
• Horner-Wadsworth-Emmons olefination 50%
• Lactam 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Aminotransferase 100%
• Pyridoxal 5 Phosphate 100%
• Alkene 100%
• Biotin 100%
• Lactam 50%
• Chemical Stability 50%
• Alkyne 50%
• Streptomyces 50%