Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Jerry Ryan Holder; Rayna M. Bauzo; Zhimin Xiang; Joseph Scott; Carrie Haskell-Luevano

doi:10.1016/j.bmcl.2003.08.078

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Jerry Ryan Holder
, Rayna M. Bauzo
, Zhimin Xiang
, Joseph Scott
, Carrie Haskell-Luevano

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH₂ tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

Original language	English (US)
Pages (from-to)	4505-4509
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2003.08.078
State	Published - Dec 15 2003
Externally published	Yes

Bibliographical note

Funding Information:
This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.

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10.1016/j.bmcl.2003.08.078

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title = "Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence",

abstract = "A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.",

author = "Holder, \{Jerry Ryan\} and Bauzo, \{Rayna M.\} and Zhimin Xiang and Joseph Scott and Carrie Haskell-Luevano",

note = "Funding Information: This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.",

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AU - Holder, Jerry Ryan

AU - Bauzo, Rayna M.

AU - Xiang, Zhimin

AU - Scott, Joseph

AU - Haskell-Luevano, Carrie

N1 - Funding Information: This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.

PY - 2003/12/15

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N2 - A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

AB - A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

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DO - 10.1016/j.bmcl.2003.08.078

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Abstract

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