Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Jerry Ryan Holder, Rayna M. Bauzo, Zhimin Xiang, Joseph Scott, Carrie Haskell-Luevano

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

Original languageEnglish (US)
Pages (from-to)4505-4509
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number24
DOIs
StatePublished - Dec 15 2003
Externally publishedYes

Bibliographical note

Funding Information:
This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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