Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Jerry Ryan Holder; Rayna M. Bauzo; Zhimin Xiang; Joseph Scott; Carrie Haskell-Luevano

doi:10.1016/j.bmcl.2003.08.078

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Jerry Ryan Holder, Rayna M. Bauzo, Zhimin Xiang, Joseph Scott, Carrie Haskell-Luevano

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH₂ tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

Original language	English (US)
Pages (from-to)	4505-4509
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2003.08.078
State	Published - Dec 15 2003
Externally published	Yes

Bibliographical note

Funding Information:
This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.

Publisher link

10.1016/j.bmcl.2003.08.078

Find It

Find It at U of M Libraries

Cite this

@article{6e76b48e82844f8394a6d55e4f10cc4c,

title = "Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence",

abstract = "A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.",

author = "Holder, {Jerry Ryan} and Bauzo, {Rayna M.} and Zhimin Xiang and Joseph Scott and Carrie Haskell-Luevano",

note = "Funding Information: This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.",

year = "2003",

month = dec,

day = "15",

doi = "10.1016/j.bmcl.2003.08.078",

language = "English (US)",

volume = "13",

pages = "4505--4509",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "24",

}

TY - JOUR

T1 - Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

AU - Holder, Jerry Ryan

AU - Bauzo, Rayna M.

AU - Xiang, Zhimin

AU - Scott, Joseph

AU - Haskell-Luevano, Carrie

N1 - Funding Information: This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences.

PY - 2003/12/15

Y1 - 2003/12/15

N2 - A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

AB - A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH2 tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

UR - http://www.scopus.com/inward/record.url?scp=0344495976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344495976&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2003.08.078

DO - 10.1016/j.bmcl.2003.08.078

M3 - Article

C2 - 14643357

AN - SCOPUS:0344495976

SN - 0960-894X

VL - 13

SP - 4505

EP - 4509

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this