TY - JOUR
T1 - Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India
T2 - Wave 2
AU - the LASI-DAD Authorship Team
AU - Khobragade, Pranali Y.
AU - Petrosyan, Sarah
AU - Dey, Sharmistha
AU - Dey, A. B.
AU - Lee, Jinkook
AU - Khobragade, Pranali Y.
AU - Petrosyan, Sarah
AU - Weerman, Albert
AU - Hu, Peifeng
AU - Gross, Alden L.
AU - Banerjee, Joyita
AU - Chien, Sandy
AU - Angrisani, Marco
AU - Adar, Sara D.
AU - Aksman, Leon
AU - Khandelwal, Niranjan
AU - Dhankhar, Anushikha
AU - Vishwakarrma, Harrshita
AU - Bhatankar, Swaroop
AU - Bajpai, Swati
AU - Ali, Istikhar
AU - Anwar, Masroor
AU - Gupta, Abhishek
AU - Myers, Clarice
AU - Chutani, Alka Mohan
AU - McEvoy, Claire
AU - Logan, Danielle E.
AU - Lynch, Kirsten
AU - Zhou, Ziqi
AU - Nichols, Emma
AU - Aravindakshan, Rajeev
AU - Chakrabarti, Sankha Subhra
AU - Das, Madhumita Priyadarshini
AU - De, Karishma
AU - Dhar, Minakshi
AU - Dewangan, Gevesh C.
AU - Gupta, Monica
AU - Khan, Umar Hafiz
AU - Jain, Vishakha
AU - John, John P.
AU - Kirti, Ravi
AU - Kokane, Arun
AU - Lehl, Sarabmeet Singh
AU - Mohanty, Rashmi R.
AU - Pandit, Vinay
AU - Rajguru, Chhaya
AU - Sahoo, Durgesh Prasad
AU - Sankhe, Lalit
AU - Sukumar, M.
AU - Thyagarajan, Bharat
N1 - Publisher Copyright:
© 2024 The Author(s). Journal of the American Geriatrics Society published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.
PY - 2025/3
Y1 - 2025/3
N2 - The rising burden of dementia calls for high-quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI-DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow-up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older. Respondents underwent a battery of cognitive tests, geriatric assessments, and venous blood collection. Their health and cognitive status were also assessed through an interview with a close family member or friend. Clinical consensus diagnosis was made based on the Clinical Dementia Rating®, and comprehensive data on risk factors of dementia were collected, including neurodegenerative biomarkers, sensory function, and environmental exposures. A total of 4635 participants were recruited between 2022 and 2024 from 22 states and union territories of India, accounting for 97.9% of the population in India. The response rate was 84.0%, and 71.5% of the participants provided venous blood specimen. LASI-DAD provides rich new data to study cognition, dementia, and their risk factors longitudinally in a nationally representative sample of older adults in India. Longitudinal cognitive data, together with longitudinally assessed biomarker data and novel data on sensory function and environmental exposures, provide a unique opportunity to establish associations between risk factors and biologically defined cognitive aging phenotypes.
AB - The rising burden of dementia calls for high-quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI-DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow-up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older. Respondents underwent a battery of cognitive tests, geriatric assessments, and venous blood collection. Their health and cognitive status were also assessed through an interview with a close family member or friend. Clinical consensus diagnosis was made based on the Clinical Dementia Rating®, and comprehensive data on risk factors of dementia were collected, including neurodegenerative biomarkers, sensory function, and environmental exposures. A total of 4635 participants were recruited between 2022 and 2024 from 22 states and union territories of India, accounting for 97.9% of the population in India. The response rate was 84.0%, and 71.5% of the participants provided venous blood specimen. LASI-DAD provides rich new data to study cognition, dementia, and their risk factors longitudinally in a nationally representative sample of older adults in India. Longitudinal cognitive data, together with longitudinally assessed biomarker data and novel data on sensory function and environmental exposures, provide a unique opportunity to establish associations between risk factors and biologically defined cognitive aging phenotypes.
KW - AD biomarkers
KW - Alzheimer's disease
KW - aging
KW - cognitive decline
KW - dementia
UR - https://www.scopus.com/pages/publications/85208073454
UR - https://www.scopus.com/pages/publications/85208073454#tab=citedBy
U2 - 10.1111/jgs.19252
DO - 10.1111/jgs.19252
M3 - Article
C2 - 39482079
AN - SCOPUS:85208073454
SN - 0002-8614
VL - 73
SP - 685
EP - 696
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 3
ER -