Design and in situ characterization of lipid containers with enhanced drug retention

Benjamin Wong, Cecile Boyer, Christian Steinbeck, David Peters, Jason Schmidt, Ryan Van Zanten, Bradley Chmelka, Joseph A. Zasadzinski

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.

Original languageEnglish (US)
Pages (from-to)2320-2325
Number of pages6
JournalAdvanced Materials
Volume23
Issue number20
DOIs
StatePublished - May 24 2011

Keywords

  • F PGSE NMR
  • H PGSE NMR
  • ciprofloxacin
  • drug delivery
  • liposomes
  • vesicles

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