TY - JOUR
T1 - Design and implementation of INSPPIRE
AU - Morinville, Veronique D.
AU - Lowe, Mark E.
AU - Ahuja, Monika
AU - Barth, Bradley
AU - Bellin, Melena D.
AU - Davis, Heather
AU - Durie, Peter R.
AU - Finley, Brian
AU - Fishman, Douglas S.
AU - Freedman, Steven D.
AU - Gariepy, Cheryl E.
AU - Giefer, Matthew J.
AU - Gonska, Tanja
AU - Heyman, Melvin B.
AU - Himes, Ryan
AU - Husain, Sohail
AU - Kumar, Soma
AU - Ooi, Chee Y.
AU - Pohl, John F.
AU - Schwarzenberg, Sarah Jane
AU - Troendle, David
AU - Werlin, Steven L.
AU - Wilschanski, Michael
AU - Yen, Elizabeth
AU - Uc, Aliye
PY - 2014/9
Y1 - 2014/9
N2 - OBJECTIVES: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are rare and poorly understood diseases in children. Better understanding of these disorders can only be accomplished via a multicenter, structured, data collection approach. METHODS: The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was created to investigate the epidemiology, etiologies, pathogenesis, natural history, and outcomes of pediatric ARP and CP. Patient and physician questionnaires were developed to capture information on demographics, medical history, family and social history, medications, hospitalizations, risk factors, diagnostic evaluation, treatments, and outcome information. Information collected in paper questionnaires was then transferred into Research Electronic Data Capture (REDCap), tabulated, and analyzed. RESULTS: The administrative structure of the INSPPIRE consortium was established, and National Institutes of Health funding was obtained. A total of 14 sites (10 in the United States, 2 in Canada, and 2 overseas) participated. Questionnaires were amended and updated as necessary, followed by changes made into the REDCap database. Between September 1, 2012 and August 31, 2013, a total of 194 children were enrolled into the study: 54% were girls, 82% were non-Hispanic, and 72% were whites. CONCLUSIONS: The INSPPIRE consortium demonstrates the feasibility of building a multicenter patient registry to study the rare pediatric diseases, ARP and CP. Analyses of collected data will provide a greater understanding of pediatric pancreatitis and create opportunities for therapeutic interventional studies that would not otherwise be possible without a multicenter approach.
AB - OBJECTIVES: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are rare and poorly understood diseases in children. Better understanding of these disorders can only be accomplished via a multicenter, structured, data collection approach. METHODS: The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was created to investigate the epidemiology, etiologies, pathogenesis, natural history, and outcomes of pediatric ARP and CP. Patient and physician questionnaires were developed to capture information on demographics, medical history, family and social history, medications, hospitalizations, risk factors, diagnostic evaluation, treatments, and outcome information. Information collected in paper questionnaires was then transferred into Research Electronic Data Capture (REDCap), tabulated, and analyzed. RESULTS: The administrative structure of the INSPPIRE consortium was established, and National Institutes of Health funding was obtained. A total of 14 sites (10 in the United States, 2 in Canada, and 2 overseas) participated. Questionnaires were amended and updated as necessary, followed by changes made into the REDCap database. Between September 1, 2012 and August 31, 2013, a total of 194 children were enrolled into the study: 54% were girls, 82% were non-Hispanic, and 72% were whites. CONCLUSIONS: The INSPPIRE consortium demonstrates the feasibility of building a multicenter patient registry to study the rare pediatric diseases, ARP and CP. Analyses of collected data will provide a greater understanding of pediatric pancreatitis and create opportunities for therapeutic interventional studies that would not otherwise be possible without a multicenter approach.
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U2 - 10.1097/MPG.0000000000000417
DO - 10.1097/MPG.0000000000000417
M3 - Article
C2 - 24824361
AN - SCOPUS:84907597963
SN - 0277-2116
VL - 59
SP - 360
EP - 364
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 3
ER -